Yaws Osteoperiostitis Treated with Single-Dose Azithromycin

Mass treatment with single-dose azithromycin for yaws.

BACKGROUND Mass treatment with azithromycin is a central component of the new World Health Organization (WHO) strategy to eradicate yaws. Empirical data on the effectiveness of the strategy are required as a prerequisite for worldwide implementation of the plan. METHODS We performed repeated clinical surveys for active yaws, serologic surveys for latent yaws, and molecular analyses to determi...

Single-dose azithromycin for trachoma.

Mass treatment with single-dose azithromycin for trachoma.

BACKGROUND Trachoma, caused by repeated ocular infection with Chlamydia trachomatis, is an important cause of blindness. Current recommended dosing intervals for mass azithromycin treatment for trachoma are based on a mathematical model. METHODS We collected conjunctival swabs for quantitative polymerase-chain-reaction assay of C. trachomatis before and 2, 6, 12, 18, and 24 months after mass ...

Erythrasma treated with single-dose clarithromycin.

Three patients presented to our clinic with erythrasma. The results of the clinical examination of each patient showed bilateral patches of erythema in the plicae inguinalis with minimal fine scaling and no central clearing. One patient also had a small superficial erosion in the right plica inguinalis. The results of an examination using Wood light showed coral red fluorescence in each patient...

Single-dose azithromycin for the treatment of cholera in adults.

BACKGROUND Single-dose azithromycin is effective in the treatment of severe cholera in children, but its effectiveness in adults has not been evaluated. METHODS We conducted a double-blind, randomized trial comparing the equivalence of azithromycin and ciprofloxacin (each given in a single 1-g dose of two 500-mg tablets) among 195 men with severe cholera caused by Vibrio cholerae O1 or O139. ...